Division of Infectious Diseases

Theo N. Kirkland, M.D.

Theo N. Kirkland, M.D.
Professor of Pathology & Medicine

VA Medical Center
3350 La Jolla Village Dr.
Mail Code 111F
La Jolla, CA 92161

Telephone: (858) 552-8585 Ext. 7446
Fax: (858) 552-4398
Email: tkirkland@ucsd.edu


Background

Dr. Kirkland graduated from University of Alabama, School of Medicine in 1975; after which, he continued his clinical training in Internal Medicine and Infectious Disease at UCSD. He completed his postdoctoral Training in the Laboratory of Immunology at the National Institute of Allergy and Infectious Diseases, NIH. He then joined the faculty here at UCSD in 1982.

Dr. Kirkland has served as Medical Director for the Clinical Microbiology Laboratory at the San Diego VA for many years.  He devotes much time to teaching medical students, housestaff, and Infectious Diseases fellows how to interpret microbiologic results.  He has been an Infectious Disease consultant at the VA and, in the past, the Thornton Hospital in the UC SanDiego Health System.

Dr. Kirkland served as an Editor on Infection and Immunity and has been a member of NIH and VA study sections for Infectious Diseases.  His research has been supported by the VA, the NIH, and a variety of other sources. Dr. Kirkland is a Fellow of the Infectious Disease Society.

He has taught Infectious Diseases and Medical Microbiology to medical professionals of all types.  Additionally, Dr. Kirkland has taught at Maputo Central Hospital, associated with the  Universidade Eduardo Mondlane School of Medicine in Maputo Mozambique.

Research Interests

Dr. Kirkland focuses on two issues in his research: innate immune receptors for microbial products and Coccidioides immitis (Valley Fever). His studies show that CD14 is an important receptor for bacterial lipopolysaccharide and peptidoglycan.  He demonstrates that MD-2 is an LPS receptor.  His lab also shows that dectin-1 is an important receptor for Coccidioides spherules.

He now focused on the genomics of Coccidioides.  He participated in sequencing the fungus and exploring the transcriptome of the spherule.  Two papers describing these studies are below.

Please see Dr. Kirkland’s profile on LinkedIn and ResearchGate for more information.

Selected Publications

Gene expression in human fungal pathogen Coccidioides immitis changes as arthroconidia differentiate into spherules and mature.  Suganya Viriyakosol, Akul Singhania, Joshua Fierer, Jonathan Goldberg, Theo N Kirkland, Christopher Woelk. BMC MicrobiologyDOI:10.1186/1471-2180-13-121  PMID:23714098.

The role of reactive oxygen intermediates in experimental coccidioidomycois in mice. David A Margolis, Suganya Viriyakosol, Joshua Fierer, Theo N Kirkland. BMC Microbiology DOI:10.1186/1471-2180-11-71. PMID:21481258.

Please see PubMed for complete bibliography