Karl Hostetler, M.D.
Karl Hostetler, M.D.
Professor of Medicine Emeritus, UCSD School of Medicine
Director, San Diego VA Medical Center Endocrinology Clinic
Associate Member, Rebecca and John Moores Cancer Center, UCSD
Department of Medicine
Telephone: (858) 552-8585 x2616
My laboratory is interested in the design, synthesis and evaluation of novel orally active analogs of acyclic nucleoside phosphonate antivirals for cytomegalovirus, herpes simplex, orf virus, hepatitis B and C, HIV-1, Epstein Barr virus, BK virus and poxviruses such as smallpox, monkeypox, cowpox, ectromelia, and vaccinia. We have also developed novel antiproliferative acyclic nucleoside phosphonates for human cervical cancer and other drugs which are being evaluated by the National Cancer Institute because of their high activity in the 60 human cancer cell screen. Finally, with our collaborators in the Dept. of Ophthalmology, we are also working on long duration of action strategies for viral and proliferative diseases of the retina. Our research is supported by the NIAID, NCI and the NEI.
- M.D., Western Reserve University, School of Medicine, Cleveland, OH, 1965.
- Intern, Department of Medicine, University Hospitals of Cleveland, 1965-1966
- Investigator, Marine Biological Laboratories, Woods Hole, Massachusetts, 1962-1964; 1966-1968
- USPHS Postdoctoral Trainee in Medicine, Case Western Reserve University, 1966-1969
- Resident, Department of Medicine University Hospitals of Cleveland, 1969
- Special Fellow in Endocrinology and Metabolism, Cleveland Clinic Foundation, 1969-1970
Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: Inhibitors of hepatitis C virus and HIV-1 replication
Nadejda Valiaeva, David L. Wyles, Robert T. Schooley, Julia B. Hwu, James R. Beadle, Mark N. Prichard, Karl Y. Hostetler Bioorganic & Medicinal Chemistry, 2011, 19(15), 4616-25.
Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine
Jacqueline Ruiz, James R. Beadle, R. Mark Buller, Jill Schreiwer, Mark N. Prichard, Kathy A. Keith, Kenneth C. Lewis, Karl Y. Hostetler Bioorganic & Medicinal Chemistry, Volume 19, Issue 9, 1 May 2011, Pages 2950-2958
Solution Structure of a DNA Duplex Containing the Potent Anti-Poxvirus Agent Cidofovir
Olivier Julien, James R. Beadle, Wendy C. Magee, Subhrangsu Chatterjee, Karl Y. Hostetler, David H. Evans, and Brian D. Sykes J Am Chem Soc. 2011 Feb 23; 133(7): 2264-74
Oral Hexadecyloxypropyl-Cidofovir Therapy in Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection
Fernando J. Bravo, David I. Bernstein, James R. Beadle, Karl Y. Hostetler, and Rhonda D. Cardin Antimicrob. Agents Chemother. January 2011 55: 35-41
Synthesis and Early Development of Hexadecyloxypropyl-cidofovir: An Oral Antipoxvirus Nucleoside Phosphonate
Karl Y. Hostetler: Viruses 2010, 2(10), 2213-2225
Antiproliferative Effects of Octadecyloxyethyl 9-[2-(Phosphonomethoxy)Ethyl]Guanine against Me-180 Human Cervical Cancer Cells in vitro and in vivo
Nadejda Valiaeva, Julissa Trahan, Kathy A. Aldern, James R. Beadle, Karl Y. Hostetler, Chemotherapy, 56 (1), 54-59, 2010
Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses
Nadejda Valiaeva, Mark N. Prichard, R. Mark Buller, James R. Beadle, Caroll B. Hartline, Kathy A. Keith, Jill Schriewer, Julissa Trahan, Karl Y. Hostetler Antiviral Res., 84 (3), 254-259, 2009
Alkoxyalkyl Esters of 9-(S)-(3-Hydroxy-2-Phosphonomethoxypropyl) Adenine Are Potent and Selective Inhibitors of Hepatitis B Virus (HBV) Replication In Vitro and in HBV Transgenic Mice In Vivo
John D. Morrey, Brent E. Korba, James R. Beadle, David L. Wyles, and Karl Y. Hostetler
Antimicrob. Agents Chemother. July 2009 53: 2865-2870
The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons
David L. Wyles, Kelly A. Kaihara, Brent E. Korba, Robert T. Schooley, James R. Beadle, and Karl Y. Hostetler Antimicrob. Agents Chemother. June 2009 53: 2660-2662
Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art Karl Y. Hostetler Antiviral Research, Volume 82, Issue 2, May 2009, Pages A84-A98