Division of Infectious Diseases

John Guatelli, M.D.

John Guatelli, M.D.
Professor of Medicine

9500 Gilman Drive # 0679
La Jolla, CA 92093-0679

Telephone: (858) 552-8585 ext 2603
Fax: (858) 552-7445
Email: jguatelli@ucsd.edu

 


Background

John Guatelli recieved his B.A. in Molecular, Cellular, and Developemental Biology from the University of Colorado in 1978, and his M.D. from the University of California, San Diego, in 1984. After training in Internal Medicine and Infectious Disease, he has been a faculty member of the UCSD School of Medicine, where he is currently a Professor of Medicine in the Division of Infectious Diseases. Dr. Guatelli is affiliated with the Biomedical Scientist Program and the Physician Scientist Training Pathway.

Research Interests

Dr. Guatelli's research lab is focused on the molecular virology of HIV-1 replication, emphasizing the accessory proteins Vpu and Nef. These proteins provide immune evasion functions: Vpu counteracts the innate defense protein BST-2, an interferon-induced cellular protein whose antiviral activity was co-discovered in the lab, whereas Nef counteracts cytotoxic T lymphocytes by modulating and degrading class I MHC, thereby inhibiting viral antigen-presentation and immune surveillance. In addition to these specific and long-term interests, the lab is engaged in proteomic discovery projects to identify new viral-host protein interactions and relationships. Through multidisciplinary collaborative research, a overarching goal of the lab is to develop detailed cell biological, biochemical, and structural models of these viral-host interactions and ultimately to exploit them for the development of antiviral therapeutics.

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