Joshua Fierer, M.D.
Joshua Fierer, M.D.
Michael and Marci Oxman Professor of Medicine and Pathology
Chief, Infectious Diseases Section, VA San Diego Healthcare System
Director, Microbiology Laboratory, VA San Diego Healthcare System
Dr. Fierer graduated from NYU School of Medicine and then did a residency in Internal Medicine at Yale-New Haven Hospital, sandwiched around a two year stint in the Epidemic Intelligence Service at CDC. He did his Infectious Diseases Fellowship training with Abraham Braude at the University of Pittsburgh and then at UCSD. He joined the faculty at UCSD School of Medicine as an Assistant Professor in 1971 and has remained at that institution ever since.
The focus of his research is host-pathogen interactions, emphasizing Salmonella enterica and Coccidioides immitis. Most recently, his research has focused on the role of innate immunity in resistance to Salmonella infections, and on the genetic basis of resistance to coccidioidomycosis, using murine infections as model systems. Resistance genes are being mapped in mice, and the interplay between these genes and cytokine responses to infection is under investigation. Dr. Fierer is a Fellow of the Infectious Diseases Society of America, AAAS, and the American Academy of Microbiology.
1959:Columbia – B.A.
1963:New York University - M.D.
1963-1964: Grace New Haven Hospital - Internship
1966-1968: Yale New Haven Hospital Residency
1968 l969: University of Pittsburgh - Research Fellow
1969 1971: University of California, San Diego - Research Fellow
- Fierer, J., Walls, L., Eckmann, L., Yamamoto, T., and Kirkland, T.; Importance of interleukin-10 in genetic susceptibility of mice to Coccidioides immitis. Infect. Immun. 66:4397-4402, 1998.
- Fierer, J., Walls, L., Kirkland, T.N.: Genetic evidence for the role of the Lv locus in early susceptibility but not IL-10 synthesis in experimental coccidioidomycosis in C57BL mice. J.Infect.Dis. 181:681-685, 2000.
- Lesnick, M.L., Reiner, N.E., Fierer, J., and Guiney, D.G.: The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cells. Mol. Microbiol. 39:1464-1470, 2001.
- Fierer, J., Swancutt, M.A., Heumann, D., and Golenbock, D.: The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. J. Immunol. 168:6396-6403, 2002.
- Viriyakosol, S., Fierer, J., Brown, G.D., and Kirkland, T.N.: Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun. Mar;73(3):1553-60, 2005.
- Margolis DA, Viriyakosol S, Fierer J, Kirkland TN. The role of reactive oxygen intermediates in resistance to coccidioidomycosis in mice. BMC Microbiol. 11;11:71.2011 .
- Fierer J, Burton DW, Haghighi P, Deftos LJ. Hypercalcemia in disseminated coccidioidomycosis: expression of parathyroid hormone-related Peptide is characteristic of granulomatous inflammation. Clin Infect Dis. 2012 Oct;55(7):e61-6. Epub 2012 Jun 5.
- Valle-Garay E, Montes AH, Corte JR, Meana A, Fierer J, Asensi V. tPA Alu (I/D)polymorphism Associates with bacterial osteomyelitis. J Infect Dis. 2013 May 2. [Epub ahead of print]
- Viriyakosol S, Jimenez Mdel P, Gurney MA, Ashbaugh ME, Fierer J. Dectin-1 is required for resistance to coccidioidomycosis in mice. MBio. 2013 Feb 5;4(1):e00597-12. doi: 10.1128/mBio.00597-12.