Division of Infectious Diseases

Nadejda Valiaeva, PhD

Ph.D
Associate Project Scientist

UCSD
Department of Medicine 

Mail Code 0676
9500 Gilman Dive
La Jolla, CA 92093-0676

Telephone: (858) 552-8585 x2614
Fax: (858) 534-6133 
email: nvalieav@ucsd.edu


Research Interests

My background is in organic synthesis of organophosphorous and heterocyclic compounds with potential biological activity. Also in medical chemistry and drug delivery of antiviral and antiproliferative agents.

Educational Background

Selected Publications

Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: Inhibitors of hepatitis C virus and HIV-1 replication Nadejda Valiaeva, David L. Wyles, Robert T. Schooley, Julia B. Hwu, James R. Beadle, Mark N. Prichard, Karl Y. Hostetler Bioorganic & Medicinal Chemistry, 2011, 19(15), 4616-25.


Antiproliferative property of hexadecyloxypropyl 9-[2-(phosphonomethoxy) ethyl] guanine (HDP-PMEG) for unwanted ocular proliferation Jiangping Hou, Yuli Li, Zhonglou Zhou, Nadejda Valiaeva, James R. Beadle, Karl Hostetler, William R. Freeman, Dan-Ning Hu, Hao Chen, Lingyun Cheng”  Molecular Vision, 17 (72), 627-637. 2011.

 
Antiproliferative Effects of Octadecyloxyethyl 9-[2-(Phosphonomethoxy)Ethyl]Guanine against Me-180 Human Cervical Cancer Cells in vitro and in vivo Nadejda Valiaeva, Julissa Trahan, Kathy A. Aldern, James R. Beadle, Karl Y. Hostetler, Chemotherapy, 56 (1), 54-59, 2010

 
Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses Nadejda Valiaeva, Mark N. Prichard, R. Mark Buller, James R. Beadle, Caroll B. Hartline, Kathy A. Keith, Jill Schriewer, Julissa Trahan, Karl Y. Hostetler Antiviral Res., 84 (3), 254-259, 2009