Maile Young Karris, M.D.
Maile Young Karris, MD
Assistant Professor of Medicine & VMRF- Research Biologist
Dr. Karris’s major research interests are:
- Characterization of the biology of HIV-1 latency in a primary CD4 T lymphocytes in vitro model
- Evaluation of the effect of pH on HIV transmission
- Characterization of the effects of cART on systemic and GALT associated T cells in acutely infected individuals
Maile Karris, MD, graduated first in class from the John A. Burns School of Medicine at the University of Hawaii. She completed her Internal Medicine Residency at Oregon Health and Sciences University and her Infectious Diseases fellowship at the University of California San Diego, where she currently resides as an Associate Professor of Medicine in the Division of Infectious Diseases.
Her effort is evenly divided between clinical duties in the HIV medicine outpatient clinic and infectious diseases inpatient consultation and in the performance of HIV clinical and translational research. Dr. Karris has trained under Drs. Douglas Richman, Davey Smith, Richard Haubrich and Celsa Spina to better understand the immunology of HIV and its role on clinical outcomes.
Research and Education
Currently, Dr. Karris’ research interests stem from “bedside-to-bench” in that she pursues research questions that directly respond to the day-to-day needs of her patients. Examples of her current research interests include a better understanding of the barriers and facilitators that contribute to poor HIV linkage and retention, a better understanding of the biology and delivery of PrEP for HIV prevention and the impact of inflammation and other factors on the successful aging of persons living with HIV. To accomplish these goals, she is a member of UC San Diego’s Center For AIDS Research Clinical Research Core.
Dr. Karris also participates in the mentoring and education of medicine residents and infectious diseases fellows historically participating in UC San Diego’s medical microbiology and HIV pharmacology courses along with educational conferences in the departments of medicine and infectious disease and community based and international lecturing on various HIV topics.
- Karris MY, Anderson CM, Morris SR, Smith DM, Little SJ. The Cost of Missing Acute HIV Infection: Testing Antibodies, Antigens and Nucleic Acids. J Clin Microbiol. 2012 March 21 [epub ahead of print]. PMID 22442319
- Soto P, Karris M, Spina C, Richman D, Varki A. Cell-Intrinsic Mechanism Involving Siglec-5 Associated with Divergent Outcomes of HIV-1 Infection in Human and Chimpanzee CD4 T Cells. J Mol Med. 2012 Sep 4. PMID 22945238
- Perez-Santiago J, Gianella S, Massanella M, Karris M, Var S, Patel D, Jordan P, Little S, Richman D, Smith D. Gut Lactobacillales are Associated with Higher CD4 and Less Microbial Translocation during HIV Infection. AIDS. 2013 March 18. PMID 22945238
- Karris MY, Kao Y, Patel D, Dawson M, Woods S, Vaida F, Spina C, Richman D, Little S, Smith D. Predictors of Virologic Suppression in Persons who Start Antiretroviral Therapy during Recent HIV Infection. AIDS 2014 Mar 27, PMID 24401640
- Karris MY, Beekman S, Mehta S, Anderson C, Polgreen P. Are We Prepped for PrEP? Provider Opinions on the Real-World Use of PrEP in the U.S. and Canada. Clin Infect Dis 2014 Mar. PMID 24319083
- Karris MY, Jain S, Bowman V, Rieg G, Goicoechea M, Dube MP, Kerkar S, Kemper C, Diamond C, Sun X, Daar ES, Haubrich RH, Morris S. Nucleoside Sparing Regimens with Raltegravir and a Boosted Protease Inhibitor: An Unsettled Issue. J Infect Dis. 2016 Mar 12. [Epub ahead of print] PMID 26977746
- Karris MY, Smith D. Tissue Specific HIV: Why it Matters. Future Virology. Future Virology. 2011 Jul 6(7): 869-882
- Karris, MY. Pre-exposure prophylaxis to prevent HIV infection: Why we need it, what are the limitations, and can we successfully provide it today? LGBT Health. Dec 2014
- Karris MY, Beekman SE, Mehta SR, Polgreen PM. Reply to Sachdev et al. Clin Infect Dis. 2014 Apr. PMD 24l729555
- Karris MY, Haubrich RH. Antiretroviral therapy in the elite controller, justified or premature? J Infect Dis. 2014. Doi 10.1093/infdis/jiu812