Division of Infectious Diseases

Kathy Aldern, BS

Department of Medicine
Mail Code 0676
UCSD, 9500 Gilman Drive
La Jolla, CA 92093-0676

 

Telephone: 858 552-8585 x7133


Research Interests

I do various cell experiments to determine toxicity and antiviral efficacy of our compounds against HIV, CMV, and HSV. I also do analytical chemistry using the two HPLCs in the labaratory. Projects include purity testing of our compound library and metabolic studies from cells and animal tissues with and without radiolabled drug.

Educational Background

BS degree, San Diego State University, 1982

Selected Publications

Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.
 Valiaeva N, Trahan J, Aldern KA, Beadle JR, Hostetler KY.
 Chemotherapy. 2010;56(1):54-9.

Intravitreal crystalline drug delivery for intraocular proliferation diseases.
Cheng L, Hostetler K, Valiaeva N, Tammewar A, Freeman WR, Beadle J, Bartsch DU, Aldern KA, Falkenstein I.
Invest Ophthalmol Vis Sci. 2010 Jan;51(1):474-81.

Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand.
Magee WC, Aldern KA, Hostetler KY, Evans DH.
Antimicrob Agents Chemother. 2008 Feb;52(2):586-97.

Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.
Painter GR, Almond MR, Trost LC, Lampert BM, Neyts J, De Clercq E, Korba BE, Aldern KA, Beadle JR, Hostetler KY.
Antimicrob Agents Chemother. 2007 Oct;51(10):3505-9.  Erratum in: Antimicrob Agents Chemother. 2007 Dec;51(12):4538

Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.
Aldern KA, Ciesla SL, Winegarden KL, Hostetler KY.
Mol Pharmacol. 2003 Mar;63(3):678-81