Division of Infectious Diseases and Global Public Health

James R. Beadle, Ph.D

Department of Medicine
Mail Code 0676
UCSD, 9500 Gilman Drive
La Jolla, CA 92093-0676

Telephone: (858) 552-8585 ext. 5955   
fax:  (858) 534-6133
Email: jbeadle@ucsd.edu

Research Interests

I am interested in the synthesis and evaluation of orally active antiviral drugs, especially acyclic nucleoside phosphonates with inhibitory activity agaianst smallpox, cytomegalovirus, hepatitis C and HIV-1.  I am also trying to develop sustained release antiproliferative nucleoside analogs for eye diseases such as proliferative vitreoretinopathy.

Educational Background

Selected Publications

Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication.  Valiaeva N, Wyles DL, Schooley RT, Hwu JB, Beadle JR, Prichard MN, Hostetler KY.  Bioorg Med Chem. 2011 Aug 1; 19(15):4616-25.

Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine. 
Ruiz J, Beadle JR, Buller RM, Schreiwer J, Prichard MN, Keith KA, Lewis KC, Hostetler KY.  Bioorg Med Chem. 2011 May 1; 19(9):2950-8.

Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir. 
Julien O, Beadle JR, Magee WC, Chatterjee S, Hostetler KY, Evans DH, Sykes BD.  J Am Chem Soc. 2011 Feb 23;133(7):2264-74.

Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection.  Bravo FJ, Bernstein DI, Beadle JR, Hostetler KY, Cardin RD.  Antimicrob Agents Chemother. 2011 Jan; 55(1):35-41.

Synthesis of cidofovir and (S)-HPMPA ether lipid prodrugs. 
Beadle JR.  Curr Protoc Nucleic Acid Chem. 2007 Jun;Chapter 15:Unit 15.2.