Gabriel Wagner, M.D.
Assistant Professor of Medicine
Center for AIDS Research
Telephone: (858) 552-7439
Dr. Wagner received his Bachelor of Arts in Biology, Biochemistry, and French from Case Western Reserve University in Cleveland, Ohio. He earned his Medical Doctorate in 2006 from The University of Toledo College of Medicine in Toledo, Ohio, and subsequently moved back to Cleveland to complete internship and residency training in internal medicine at the Cleveland Clinic. In 2009, he began fellowship training in infectious diseases at the University of California San Diego (UCSD), where he underwent four years of extensive clinical translational research training in HIV/AIDS at the Center for AIDS Research and the Antiviral Research Center under Dr. Davey Smith. During this tenure, he undertook didactic coursework in clinical research through the UCSD CREST program, and he also successfully completed the Interdisciplinary Research Fellowship in NeuroAIDS (2011-2013) at the UCSD HIV Neurobehavioral Research Center. Dr. Wagner joined the UCSD faculty in 2014 and continues his research work in HIV/AIDS, as well as maintaining active clinical duties by providing care to HIV-infected patients at the UCSD Owen Clinic.
Dr. Wagner’s primary research interests revolve around the study of HIV superinfection, i.e. re-infection of an individual by a second HIV strain. Unlike most viral infections, humans can be re-infected by HIV, a phenomenon that underlines the inadequacy of the HIV-directed immune response. By utilizing next generation sequencing to enhance the sensitivity of detection of HIV superinfection, he and his colleagues have identified several such study participants that can be further studied to (1) better understand correlates of protection from re-infection that can be used to inform the design of a protective HIV vaccine, and to (2) learn how HIV superinfection impacts end organ damage, specifically, the central nervous system and neurocognitive functioning.
- Wagner GA, Pacold ME, Pond SL, Caballero G, Chaillon A, Rudolph AE, Morris SR, Little SJ, Richman DD, Smith DM. Incidence and Prevalence of Intrasubtype HIV-1 Dual Infection in At-Risk Men in the United States. The Journal of Infectious Diseases; 2013 Nov 22. PMID: 24273040.
- Morris SR, Woods SP, Deutsch R, Little SJ, Wagner G, Morgan EE, Heaton RK, Letendre SL, Grant I, Smith DM. Dual-mixed HIV-1 coreceptor tropism and HIV-associated neurocognitive deficits. Journal of NeuroVirology; 2013 Sep 28. PMID: 24078557.
- Chaillon A, Wagner GA, Hepler NL, Little SJ, Kosakovsky Pond SL, Caballero G, Pacold ME, Phung P, Wrin T, Richman DD, Wertheim JO, Smith DM. Dynamics of Viral Evolution and Neutralizing Antibody Response after HIV-1 Superinfection. Journal of Virology; 2013 Sep 18. PMID: 24049166.
- Hightower GK, May SJ, Pérez-Santiago J, Pacold ME, Wagner GA, Little SJ, Richman DD, Mehta SR, Smith DM, Pond SL. HIV-1 Clade B pol Evolution following Primary Infection. PLoS One 2013; 8(6):e68188.
- Wagner GA, Pacold ME, Vigil E, Caballero G, Morris SR, Pond SL, Little SJ, Richman DD, Gianella S, Smith DM. Using Ultradeep Pyrosequencing to Study HIV-1 Co-receptor Usage in Primary and Dual Infection. The Journal of Infectious Diseases 2013; 208: 271–74.
- Pacold ME, Pond SLK, Wagner GA, Delport W, Bourque DL, Richman DD, Little SJ, Smith DM: Clinical, virologic, and immunologic correlates of HIV-1 intraclade B dual infection among men who have sex with men. AIDS 2012; 26(2): 157-65.