Division of Infectious Diseases

Anthony Cannella, M.D., M.Sc

Assistant Professor of Medicine
Division of Infectious Diseases

 

9500 Gilman Drive

Mail Code 0711

La Jolla, CA 92093-0711
Phone: 858-822-0333
Fax: 858-822-5362

Email: acannella@ucsd.edu

 


Research Interests

Dr. Cannella’s primary research interests are how the human immune system interacts with pathogens and more specifically how the adaptive immunity plays a role in this process of controlling the infection. He is interested in the adaptive immune response differences between asymptomatic patients and symptomatic patients of neglected tropical diseases, more specifically: Plasmodium (malaria), Mycobacteria tuberculosis, and Leptospira. His current project revolves around elucidating the mechanisms of how some individuals respond to an infection, demonstrated by their cytokine profiling of these individuals’ T helper cell responses (TH1/TH2/TH17/THreg) and even measurement of B cell memory capacity. Dr. Cannella believes that these fundamental immune differences between asymptomatic patients and symptomatic patients can hold the key to understanding how certain pathogens can not only evade the immune system, but also induce a response, which could impede immune control of the organism.

Background

1995-1999 BS; Biology University of South Florida
1999-2000 M.Sc.; Biomedical Science Barry University
2002-2006 M.D. University of South Florida
2006-2009 Residency University of Alabama; Birmingham
2009-2013 Fellowship UCSD

 

Selected Publications

Cannella, AP, Oehler, R Case Report: Streptococcus constellatus Bacterial Endocarditis w/ Multiple Embolic Secondary Infection. Infections in Medicine; November 2007.

Cannella, AP, Nguyen, BM, Piggott, CD, Lee, R, Vinetz, JM, Mehta, S. A Cluster of Cutaneous Leishmaniasis Associated with Human Smuggling. Am. J. Trop. Med. Hyg., 84(6), 2011, pp. 847–850 PMID: 21633017 doi:10.4269/ajtmh.2011.10-0693

King, J, McCall, M, Cannella, A, Markiewicz, MA, James, A, Hood, CB, Acosta, EP. A Randomized Crossover Study to Determine Relative Bioequivalence of Tenofovir, Emtricitabine, and Efavirenz (Atripla) Fixed-Dose Combination Tablet Compared With a Compounded Oral Liquid Formulation Derived From the Tablet. JAIDS (Journal of Acquired Immune Deficiency Syndromes) 56(5):e131-e132, April 15, 2011. PMID: 22046602

Cannella AP, Lin JC, Liang L, Atluri V, Gotuzzo E, Felgner PL, Tsolis RM, Vinetz JM. Serial Kinetics of the Antibody Response Against the Complete Brucella melitensis ORFeome in Chronic Human Brucellosis. J Clin Microbiol. 2012 Mar;50(3):922-6. doi: 10.1128/JCM.05298-11. Epub 2012 Jan 4. PMID: 22219303

Cannella AP, Tsolis RM, Liang L, Felgner PL, Saito M, Sette A, Gotuzzo E, Vinetz JM. Front Cell Infect Microbiol. Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development. Frontiers in Cellular and Infection Microbiology 2012;2:1. doi: 10.3389/fcimb.2012.00001. Epub 2012 Feb 1.PMID: 22919593

*McKinnell JA, *Cannella AP, Kunz DF, Hook EW 3rd, Moser SA, Miller LG, Baddley JW, Pappas PG. Pneumocystis Pneumonia; A Detailed Examination of Symptoms, Management, and Outcomes in HIV-infected and HIV-uninfected Persons. Transpl Infect Dis. 2012 Oct;14(5):510-8. doi: 10.1111/j.1399-3062.2012.00739.x. Epub 2012 May 1.PMID: 22548840 *: Co-first author

Cannella AP, Lindestam Arlehamn CS, Sidney J, Patra KP, Torres K, Tsolis RM, Liang, L, Felgner, PL, Saito M, Gotuzzo E, Gilman RH, Sette A, Vinetz. Brucella melitensis T cell Epitope Recognition by Humans Recovered From Brucellosis in Peru. Infect Immun. 2013 Oct 14. PMID: 24126518

Lehmann JS, Fouts DE, Haft DH, Cannella AP, Ricaldi JN, Brinkac L, Harkins D, Durkin S, Sanka R, Sutton G, Moreno A, Vinetz JM, Matthias MA. Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans. PLoS Negl Trop Dis. 2013 Oct 3;7(10):e2468. PMID: 24098822